Acute Tox - Logo

 

Publications during 2008

 

General publications

Sjöström M., Kolman A., Clemedson C. and Clothier R. Estimation of human blood LC50 values for use in modelling of in vitro –in vivo data of the ACuteTox  project. Toxicology in Vitro 22(2008) 1405-1411. Article 


Kinsner A. , Bulgheroni A., Prieto P. ECVAM ongoing activities to meet the cosmetics 2009 deadline related to acute oral toxicity 15th International Congress on In Vitro Toxicology, 25 - 28 Sept 2008, Stockholm, Sweden. Abstract Oral presentation.

 

ACuteTox Executive summary.

Image Download pdf 75 kB

 

WP2

Clothier R., Dierickx P., Lakhanisky T., Fabre M., Betanzos M., Curren R., Sjöström M., Rabbe H., Bourne N., Hernandez V., Mainez J., Owen M., Watts S. and Anthonissen R.  DATABASE OF IC50 VALUES AND PRINCIPLE COMPONENT ANALYSIS OF SIX BASAL CYTOTOXICITY ASSAYS, FOR USE IN MODELING OF IN VITRO – IN VIVO DATA OF THE ACUTETOX PROJECT   Article Manuscript.

 

WP3

Kinsner-Ovaskainen A., Rzepka R., Rudowski R., Coecke S., Cole T. and Prieto P. Acutoxbase – an innovative database for in vitro acute toxicity studies  Article Manuscript.


Sjöström M.,  Kolman A.,  Clemedson C. Multivariate methods for analyses of in vitro data and for in vitro-in vivo modeling 15th International Congress on In Vitro Toxicology, 25 - 28 Sept 2008, Stockholm, Sweden. Abstract Oral presentation.

 

WP4

Cerrato L., Bueren J.A. and Albella B. "Relationship between the in vitro effect of chemicals on human myeloid progenitors
and the human peak plasma levels inducing toxicity." 44th Congress of the European Societies of Toxicology in Rhodes 2008 (EUROTOX2008) Abstract 


WP5 

Turco L., Catone T., Caloni F., Testai E. and Stammati A. Caco-2/TC7 cell line characterization for intestinal absorption: a reliable in vitro model for the prediction  of the oral dose fraction absorbed in human. 15th International Congress on In Vitro Toxicology, 25 - 28 Sept 2008, Stockholm, Sweden. Abstract Oral presentation.


Blaauboer B. J.  Kinetic considerations for the interpretation of in vitro toxicity data in risk assessment 15th International Congress on In Vitro Toxicology, 25 - 28 Sept 2008, Stockholm, Sweden. Abstract Oral presentation.


Hallier-Vanuxeem D., Landry C., Culot M., Nion S., Dehouck M.P. and Cecchelli R. A rapid in vitro model for Blood-Brain Barrier screening of neurotoxic chemicals. 15th International Congress on In Vitro Toxicology, 25 - 28 Sept 2008, Stockholm, Sweden. Abstract Oral presentation.


WP6 

Donato M.T., Lahoz A., Castell J.V. and Gómez-Lechón M.J. Cell lines: A tool for in vitro drug metabolism studies. Curr Drug Metab. (in press) Article Manuscript.


Donato M.T., Castell J.V. and Gómez-Lechón M.J. In vitro P450 inhibition/induction in early drug Development.  Expert Opinion on Drug Metabolism and Toxicology (in press) Article Manuscript.


Lahoz A., Donato M.T., Montero S., Castell J.V. and Gómez-Lechón M.J. In vitro cocktail assay for the simultaneous determination of phase I and phase II enzymatic activities of human hepatocyte preparations.  Rapid Communications in Mass Spectrometry 22: 240–244, 2008. Article 


Lahoz A., Donato M.T., Castell J.V. and Gómez-Lechón M.J.  Strategies to in vitro assessment of major human CYP enzyme activities by using liquid chromatography tandem mass spectrometry. Curr Drug Metab. (in press) Article Manuscript.


Pascual M., Gómez-Lechón M.J., Castell J.V. and Jover R.  ATF5, a highly abundant liver-specific transcription factor, cooperates with CAR in the transactivation of CYP2B6: Implications in hepatic stress response.  Drug Metab Disp (in press) Article Manuscript.


WP7.1 

Bal-Price A.K., Suñol C., Weiss D.G., van Vliet E. and Remco H.S.  Application of in vitro neurotoxicity testing for regulatory purposes: Symposium III Summary and Research Needs. Neurotoxicology (submitted).  Article Manuscript.


Honegger P., Tavel D. and Zurich M.G. Aggregating brain cell cultures as a model for acute neurotoxicity testing. Neurotoxicoloy (in press).  Article Manuscript.


Suñol C., Babot Z., Fonfría E., Galofré M., García D., Herrera N., Iraola S. and Vendrell I.  Studies with neuronal cells: from basic studies of mechanisms of neurotoxicity to the prediction of chemical toxicity. Toxicology In Vitro (submitted).  Article Manuscript.


Yeste-Velasco M, Alvira D, Sureda F.X., Rimbau V, Forsby A., Pallàs M., Camins A. and Folch J. cDNA low density array analysis of colchicine neurotoxicity in rat cerebrellar granular cell. Neurotoxicoloy (in press).  Article Manuscript.


Folch J., Yeste-Velasco M.,  Alvira D., Vázquez de la Torre A., Bordas M., López M., Sureda F.X., Rimbau V., Camins A. and Pallàs M. Evaluation of pathways involved in pentachlorophenol-induced apoptosis in rat neurons   submitted to Neurotoxicology Article Manuscript.


Forsby A. Neuronal in vitro models for the estimation of acute systemic toxicity 15th International Congress on In Vitro Toxicology, 25 - 28 Sept 2008, Stockholm, Sweden. Abstract Oral presentation.


WP7.2 

McMorrow T., Campbell E., Slattery C. and Ryan M.P.  Molecular mechanisms modulating epithelial-mesenchymal transition (EMT) in human renal epithelial cells. Cell Physiology: Human epithelial neoplastic cell plasticity: Implications for tumor progression and metastasis. Editor: Paul J. Higgins, PhD (in press). Article Manuscript.


WP7.3 

Gui C., Miao Y., Thompson L., Wahlgren B., Mock M., Stieger B. and Hagenbuch B. Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. European Journal of Pharmacology 584,  57–65, 2008.  Article 


Rohacova J., Marin M.L., O’Connor J.E., Gómez-Lechón M.J., Donato M.T., Castell J.V and Miranda M.A.  Photophysical characterization and cytomic applications of cholylamidofluorescein, a fluorescent bile acid scaffold.  Anal Biochem (submitted). Article Manuscript.


Zdarilová A., Cvek B.,  Vrba J., Gómez-Lechón M.J. and Ulrichová J. Cytotoxicity of  model compounds on cell lines (3T3, HepG2) and rat hepatocytes.  Biomedical Papers, Vol. 1, 2008. Article