WP 4: New cell systems and new endpoints
Articles
Alvarez-Barrientos A., O’Connor J.E. and Callaghan R.C. Citómica: Técnicas y estrategias en citometría de sistemas. In: Las Omicas Genómica, Proteómica, Citómica y Metabolómica: Modernas Tecnologías Para el Desarrollo de Fármacos. (M. Cascales, M.J. Gómez-Lechón y J.E. O'Connor, eds.) Instituto de España-Real Academia Nacional de Farmacia, Madrid. pp. 123-154. 2005. Book chapter.
Devos S., Cormont F., Vrtala S., Hooghe-Peters E., Pirson F. and Van Snick J. Allergen induced interleukin-9 production in vitro: correlation with atopy in human adults and comparison with interleukin-5 and interleukin-13. Clinical and Experimental Allergy 36, 174-82, 2006.
Gómez-Lechón M.J., Donato M.T., Martínez-Romero A., Jiménez N., Castell J.V. and O’Connor, J.E A human hepatocellular in vitro model to investigate steatosis. Chemico-Biol Interact 165: 106–116. 2007.
Herrera G., Diaz L., Martinez-Romero A., Gomes A., Villamon E., Callaghan R.C. and O’Connor J.E. Cytomics: A Multiparametric, Dynamic Approach to Cell Research. Toxicol. In Vitro doi: 10.1016/j.tiv.2006.07.003. (A special issue of the journal Toxicology In Vitro covering the ETCS-AICC-CELLTOX meeting).
Herrera G., Diaz L., Martinez-Romero A., Gomes A., Villamon E., Callaghan R.C. and O’Connor J.E Cytomics: A Multiparametric, Dynamic Approach to Cell Research. Toxicol. 21:176-182. 2007.
O’Connor J.E., Herrera G., Martínez-Romero A., Bodi C., Valero C., Callaghan R.C. and Monteiro M.C. La citometría de flujo en el analisis citómico: in vivo, in vitro, ¿in fluxo? In: Las Omicas Genómica, Proteómica, Citómica y Metabolómica: Modernas Tecnologías Para el Desarrollo de Fármacos. (M. Cascales, M.J. Gómez-Lechón y J.E. O'Connor, eds.) Instituto de España-Real Academia Nacional de Farmacia, Madrid. pp. 183-206. 2005. Book chapter.
O’Connor J.E., Alvarez-Barrientos A., Callaghan R.C., Herrera G. and Martínez-Romero A. La Citómica como estrategia alternativa en Farmacología y Toxicología in vitro. In: Las Omicas Genómica, Proteómica, Citómica y Metabolómica: Modernas Tecnologías Para el Desarrollo de Fármacos. (M. Cascales, M.J. Gómez-Lechón y J.E. O'Connor, eds.) Instituto de España-Real Academia Nacional de Farmacia, Madrid. pp.155-182. 2005. Book chapter.
Abstracts
Cerrato L., Gómez S.G., Bueren J.A. and Albella B. Role of the in vitro hematopoietic cultures in the european project A-Cute-Tox. 3rd Congress of the European Societies of Toxicology and 6th Congress of Toxicology in Developing Countries, Cavtat, Croatia, September 2006. (Toxicol. Lett. 164S: S2044).
Cerrato L., Gómez S.G., Bueren J.A. and Albella B. In vitro myeloid haematopoietic cultures (CFU-GM) in the european Project A-Cute-Tox. 3rd Meeting of the A-Cute-Tox Consortium, Ostende, October 2006.
Cerrato L., Gómez S.G., Bueren J.A. and Albella B. Papel de los cultivos hematopoyeticos en la prevalidación de Estrategias in vitro para predecir toxicidad aguda en humanos. XIX Congreso Nacional. Asociación Española de Técnicos de Laboratorio. May 2006 .
Cerrato L., Bueren J. A. and Albella B. PAPEL DE LOS CULTIVOS HEMATOPOYETICOS DE PRECURSORES MEGACARIOCÍTICOS EN LA PREVALIDACIÓN DE ESTRATEGIAS IN VITRO PARA PREDECIR TOXICIDAD AGUDA EN HUMANOS. XX Congreso Nacional, Asociación Espanola de Técnicos de la Laboratorio, 2007.
Abstract pdf 27 kB
Cerrato L., Bueren J. A. and Albella B. Toxicity of Chemicals Involved in the European Project A-Cute-Tox on the Myeloid Hematopoietic Progenitors. 44th Congress of the European Societies of Toxicology in Amsterdam 2007 (EOROTOX2007).
Abstract pdf 17 kB
Cerrato L., Bueren J.A. and Albella B. Relationship between the in vitro effect of chemicals on human myeloid progenitors and the human peak plasma levels inducing toxicity. 44th Congress of the European Societies of Toxicology in Rhodes 2008 (EUROTOX2008).
Abstract pdf 13 kB
Devos S., Hooghe R., Hooghe-Peters E., Kooijman R., O’Connor J.E., Villamón E. and Gómez A. Changes in cytokine production in vitro as indicators for immunotoxicity. III Meeting of the A-Cute-Tox Consortium, Ostende, October 2006. Poster.
Diaz L., Gomes A., Pinto S., Parra M., Callaghan R.C., Herrera G. and O´Connor J.E. In Vitro Strategies for Predicting Human Acute Toxicity: Screening Oxidative Cytotoxity by Flow Cytometry and High Content Assays. Free Radical Research, 41: 23. 2007.
Herrera G., Martínez A., Bodi C., Díaz-Vico L., Gil-Casanova D., Callaghan R.C. and O’Connor J.E. Novel flow cytometric assays of oxidative stress and oxidative damage to DNA for assessing sustained in vitro cytotoxicity. XXVIII Congreso de la Sociedad Española de Bioquímica y Biología Molecular, Zaragoza, Spain, September 2005. Poster.
Herrera G., Díaz L., Gil D., Navarro C. and O’Connor J.E. 96-well Plate Flow Cytometry: A Novel Cytomic Approach for Rapid Screening for In Vitro Toxicology. 46th ETCS International Meeting/3rd International Joint Meeting AICC-Celltox on "In Vitro Cytotoxicity Mechanisms" Verona, March 2006.
Herrera G., Martinez-Romero A., Diaz L., Villamon E., Callaghan R.C. and O’Connor J.E. Cytomics: A Multiparametric, Dynamic Approach to Cell Research. XXIX Congreso de la Sociedad Española de Bioquímica y Biología Molecular, Alicante, September 2006.
Herrera G., Martinez-Romero A., Callaghan R.C., Villamon E., Diaz L., Valero L., Gil D., Navarro C., Bodi C. and O’Connor J.E. Cytomics: A Multiparametric, Dynamic Approach to Cell Research. 46th ETCS International Meeting/3rd International Joint Meeting AICC-Celltox on "In Vitro Cytotoxicity Mechanisms" Verona, March 2006.
Herrera G., Díaz L., Gomes A., Villamón A., Callaghan R.C. and O’Connor J.E. Miniaturized Screening of Cytotoxicity by Cytomic Assays. III Meeting of the A-Cute-Tox Consortium, Ostende, October 2006. Poster.
Herrera G., Pinto S., Diaz L., Gomes A., Parra M., Arenas M., Callaghan R.C. and O´Connor J.E. Assessment of Oxidative Damage to DNA by Flow Cytometry and High Content Bioimaging Assays. Free Radical Research, 41: 23. 2007.
Martínez-Romero A., O’Connor J.E., Herrera G., Díaz L., Alvarez-Barrientos A. and Callaghan R.C. The role of Cytomics in the test strategies for chemical risk evaluation: The European integrated project A-Cute-Tox. IX Congresso da Sociedade Ibérica de Citometría, Porto (Portugal), May 2005. Poster.
Martínez-Romero A., Álvarez-Barrientos A., Callaghan R.C., Prieto P. and O'Connor J.E. Use of V79 Cells Expressing CYP2D6 for Cytomic Analysis of Biotransformation-Dependent and Independent Cytotoxicity. 46th ETCS International Meeting/3rd International Joint Meeting AICC-Celltox on "In Vitro Cytotoxicity Mechanisms" Verona, March 2006.
O’Connor J.E. Citómica: Una nueva frontera en Biología Celular. Workshop “Nuevas Tecnologías”. XI Congreso de la Sociedad Española de Biología Celular, Cádiz, (Spain), November 2005. Oral presentation.
O’Connor J.E., Herrera G., Martínez-Romero A., Díaz L., Alvarez-Barrientos A. and Callaghan R.C. La Citómica en las estrategias generales de detección de toxicidad aguda: El proyecto integrado A-Cute-Tox. IX Congresso da Sociedade Ibérica de Citometría, Porto (Portugal), May 2005. Oral presentation.
Pinto S., Diaz L., Herrera G., Gómez-Lechón M.J., Donato T., Castell J.V. and O´Connor J.E. High Content Bioimaging Assays for Oxidative Stress Assessment in Primary Cultures of Hepatocytes. Free Radical Research, 41: 23. 2007.
Seminars & Lectures
O’Connor J.E. Citometria de Fluxo e Citocinas. Laboratório Doutor Chaves, Lisboa (Portugal), November 2005.
O’Connor J.E Análisis funcional por citometría de flujo. V Curso Teórico-Práctico de Citometría de Flujo. CIEMAT/CNIC, Madrid, November 2005.
O’Connor J.E. Laboratorio de Citómica. Centro de Investigación “Príncipe Felipe”, Valencia (Spain), April 2005.
Others
Devos S. Expression of IL-9 and allergy - Effects of some organic pollutants on the immune response with special concern for allergy. Facultieit geneeskunde en famacie dienst farmacologie, Vrije Universiteit Brussel, 2006-2007. PhD Thesis.



