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WP 5: Role of adsorption, distribution and elimination

 

Articles

Blaauboer B.J., Hermens J. and van Eijkeren J. Estimating acute toxicity based on in vitro cytotoxicity: role of biokinetic modelling. 5th World Congress on Alternatives & Animal Use in the Life Sciences, Berlin, August 21-25, 2005. ALTEX 23, Special issue 2006. 


Culot M., Nion S., Landry C., Delplace Y.,  Dehouck M-P., Berezowski V., Fenart V. and Cecchelli R. An in vitro model of Blood-Brain Barrier for high throughput pharmatoxicological screening.  Toxicology in Vitro (submitted).  Manuscript.


Guerra A., Paez J.A. and Campillo N. E. Artificial Neural Networks in ADMET Modeling: Prediction of Blood-Brain Barrier Permeation QSAR & Combinatorial Science. 2007. DOI: 10.1002/qsar.200710019 


Hubatsch I., Ragnarsson E. G. E. and Artursson P. Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers.   Manuscript.


Kramer N.I., van Eijkeren J.C.H. and Hermens J.L.M. Influence of albumin on sorption kinetics in solid-phase microextraction: consequences for chemical analyses and uptake processes.  Anal. Chem., 79 6941-6948, 2007.


 

Abstracts

Blaauboer B. The role of biokinetic information in the interpretation of in vitro cytotoxicity data: an essential part of estimating acute toxicity in the AcuteTox programme. 5th World Congress on Alternatives & Animal Use in the Life Sciences, Berlin, August 21-25, 2005. ALTEX 22, Special Issue 2005. Oral presentation.

 

Blaauboer B. J. Kinetic considerations for the interpretation of in vitro toxicity data in risk assessment. 15th International Congress on In Vitro Toxicology, 25 - 28 Sept 2008, Stockholm, Sweden. Oral presentation.   Image Abstract pdf 17 kB



Caloni F., Catone T., De Angelis I., Di Consiglio E., Testai E., Turco L., Zucco F. and Stammati A. Relevance of absorption in acute toxicity studies. 46th ETCS International Meeting/3rd International Joint Meeting AICC-Celltox on "In Vitro Cytotoxicity Mechanisms" Verona, March 2006. Poster.


Campillo N.E., Guerra  A. and Páez J.A.  Applicación de diferentes modelos de redes neuronales artificiales (RNA) a problemas de la química médica. Conference at the faculty of Chemistry, University of Montevideo, Uruguay, 2005.  Image Abstract pdf 124 kB


Campillo N.E. Codes: A Topological Method To Encode Chemical Structures Based on Neural Computing. Application in Biokinetic Parameters Prediction.  Conference at IVTIP Plenary Meeting, Madrid, Spain, 2005.  Image Abstract pdf 14 kb


Guerra A., Campillo N.E. and Páez J.A. Artificial neural networks in medicinal chemistry. XVI Congreso Nacional de la Sociedad Española de Química Terapéutica held in Bilbao (Spain), September 2005. 

 

Hallier-Vanuxeem D., Landry C., Culot M., Nion S., Dehouck M.P. and Cecchelli R. A rapid in vitro model for Blood-Brain Barrier screening of neurotoxic chemicals. 15th International Congress on In Vitro Toxicology, 25 - 28 Sept 2008, Stockholm, Sweden.  Oral presentation.  Image Abstract 19 kB



Kramer N.I., Krismartina M., Blaauboer B.J. and Hermens J.L.M. Measuring and modeling bioavailability in in vitro systems. Chem-Biol Interact 169, p.137. 2007. Abstract.  Image Abstract pdf 49 kB

 

Turco L., Catone T., Caloni F., Testai E. and Stammati A. Caco-2/TC7 cell line characterization for intestinal absorption: a reliable in vitro model for the prediction  of the oral dose fraction absorbed in human. 15th International Congress on In Vitro Toxicology, 25 - 28 Sept 2008, Stockholm, Sweden. Oral presentation.   Image Abstract pdf 18 kB

 

Others

Guerra A. Applicación de la inteligencia artificial a la predicción de propiedades ADMET: Paso de la barrera hematoencefálica.  Universidad Autónoma de Madrid , Facultad de ciencias, Departemento de Química Orgánica, 2006. Diploma work (Text and Oral).