WP 6 : Role of metabolism

 

Articles

Donato M.T., Lahoz A., Castell J.V. and Gómez-Lechón M.J. Cell lines: A tool for in vitro drug metabolism studies. Curr Drug Metab. (in press) Manuscript.

Donato M.T., Castell J.V. and Gómez-Lechón M.J. In vitro P450 inhibition/induction in early drug Development.  Expert Opinion on Drug Metabolism and Toxicology (in press) Manuscript.

Lahoz A., Donato M.T., Montero S., Castell J.V. and Gómez-Lechón M.J. In vitro cocktail assay for the simultaneous determination of phase I and phase II enzymatic activities of human hepatocyte preparations.  Rapid Communications in Mass Spectrometry 22: 240–244, 2008. 

Lahoz A., Donato M.T., Castell J.V. and Gómez-Lechón M.J.  Strategies to in vitro assessment of major human CYP enzyme activities by using liquid chromatography tandem mass spectrometry. Curr Drug Metab. (in press) Manuscript.

Martínez-Jiménez P., Jover R., Donato M.T., Castell J.V. and Gómez-Lechón M.J. CYP3A4 regulation and expression in hepatocytes C. Curr Drug Metab. 8:185-195, 2007. 

Pascual M., Gómez-Lechón M.J., Castell J.V. and Jover R.  ATF5, a highly abundant liver-specific transcription factor, cooperates with CAR in the transactivation of CYP2B6: Implications in hepatic stress response.  Drug Metab Disp (in press) Manuscript.

 

 

Abstracts

Baranczewski P., Long A., Lundgren B., Svensson R. and Garberg P.  Biotransformation of the piperazine ring and an evaluation of the expert system Meteor. 9th ISSX meeting, Manchester, UK, June 4-7, 2006. Drug Metabolism Reviews, volume 38, supplement 1, 147, 2006.   Abstract pdf 523 kB

Perez-Cataldo G., Castell M., Rodriguez-Pena R., Lopez S., Mayorga L., Blanca M. and Castell J.V. Can dendritic cells metabolise (bioactivate) drugs?: clues to investigate in vitro the onset of an hypersensitivity reaction. 14th International Workshop on In Vitro Toxicology, Ostende, Belgium, 2-5 October 2006.  Oral presentation.