WP 7.2: Role target organ toxicity (kidney)

 

Arrticles

Campbell E., Slattery C., Tuite N., Nolan S., Leonard M., Ryan M.P. and McMorrow T. RNA Interference: a Novel Alternative Approach in Nephrotoxicity Studies. 5th World Congress on Alternatives & Animal Use in the Life Sciences, Berlin, August 21-25, 2005. ALTEX 23, Special issue 2006. 

Campbell E., Slattery C., Nolan S., Feighery R., Ryan M.P. and McMorrow T. A potential role for RAP GTPases in cell adhesion and Transforming Growth Factor- 1 mediated epithelial-mesenchymal transition. European Journal of Cell Biology. (in press) Manuscript.

McMorrow T., Gaffney M.M., Slattery C., Campbell E. and Ryan M.P. Cyclosporine A - induced epithelial to mesenchymal transdifferentiation (EMT) in renal tubular epithelial cells. Nephrol. Dial. Trans. 20(10):2215-25. 2005. 

McMorrow T., Campbell E., Slattery C. and Ryan M.P.  Molecular mechanisms modulating epithelial-mesenchymal transition (EMT) in human renal epithelial cells. Cell Physiology: Human epithelial neoplastic cell plasticity: Implications for tumor progression and metastasis. Editor: Paul J. Higgins, PhD (in press). Manuscript.

Slattery C., Campbell E., McMorrow T. and Ryan M.P. Cyclosporine A - induced renal fibrosis: a role for epithelial to mesenchymal transdifferentiation. Am. J. Path. 167(2): 295-407. 2005. 

Slattery C., Campbell E., McMorrow T. and Ryan M.P.  Over-expression of E2A proteins induces epithelial mesenchymal transition in human renal proximal tubular epithelial cells suggesting a potential role in renal fibrosis. FEBS Letters 580:4021-4030. 

Slattery C., Ryan M.P. and McMorrow T.  E2A proteins - regulators of cell phenotype in normal physiology and disease. International Journal of Biochemistry & Cell Biology - Epub ahead of print doi:10.1016/j.biocel.2007.05.014 

Slattery C., O’Connell S., Ryan M.P. and McMorrow T. The Role of PKC- in Cyclosporine A-Induced Tubulointerstitial Fibrosis. International Journal of Biochemistry & Cell Biology. (in press) Manuscript.

 

Abstracts

Low C.A., Ryan G., McEwan G., Ryan M.P. and Hawksworth G.M. Optimisation of an in vitro test strategy for predicting acute Nephrotoxicity. 14th International Workshop on In Vitro Toxicology, Ostende, Belgium, 2-5 October 2006. 

Martín N., Ryan G., Anderson C., Hawksworth G. and Ryan M.P.
" Optimisation and pre-validation of an in vitro test strategy for predicting human acute toxicity. 6th World Congress on Alternatives & Animal Use in the Life Sciences, Tokyo, Japan, 20th August 2007. Poster.

Martín N., Ryan G. and Ryan M.P. Optimisation and pre-validation of an in vitro test strategy for predicting human acute toxicity. UCD Conway Festival of Research, Dublin, Ireland, 20th September 2007. Poster.

Martín N. The effect of Cyclosporine A and Rapamycin on the integrity of the cellular tight-junctional complex in renal proximal tubular cells Conway Institute Research Festival,  Dublin, Ireland, 5th September 2007. Oral presentation.