WP 7.3: Role target organ toxicity (liver)

 

Articles

Fluorescent Benzofurazan-Cholic Acid Conjugates for in vitro Assessment of Bile Acid Uptake and Its Modulation by Drugs.Rohacova J, Marín ML, Martinez-Romero A, Diaz L, O'Connor JE, Gomez-Lechon MJ, Donato MT, Castell JV, Miranda MA. ChemMedChem. 4:466-472 (2009)

 

Synthesis of new, UV-photoactive dansyl derivatives for flow cytometric studies on bile acid uptake Jana Rohacova, M. Luisa Marin, Alicia Martínez-Romero, José-Enrique O'Connor, M. Jose Gomez-Lechon, M. Teresa Donato, José V. Castell and Miguel A. Mirandaa. Org. Biomol. Chem., 2009, DOI: 10.1039/paperno.

 

In vitro evaluation of potential hepatotoxicity induced by new drugs. M. J. Gómez-Lechón, A. Lahoz, L. Gombau, J.V. Castell and M. T. Donato. Curr Pharm Design (2009) in press

de Waart D.R., Häusler S., Vlaming M.LH., Kunne C., Hänggi E., Oude Elferink R. PJ. and Stieger B. Hepatic transport mechanisms of Cholyl-Lysyl-Fluorescein. 2008. Manuscript.

 

Gui C., Miao Y., Thompson L., Wahlgren B., Mock M., Stieger B. and Hagenbuch B. Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. European Journal of Pharmacology 584,  57–65, 2008.


Zdarilová A., Cvek B.,  Vrba J., Gómez-Lechón M.J. and Ulrichová J. Cytotoxicity of  model compounds on cell lines (3T3, HepG2) and rat hepatocytes.  Biomedical Papers, Vol. 1, 2008. 

 

Rohacova J., Marin M.L., O’Connor J.E., Gómez-Lechón M.J., Donato M.T., Castell J.V and Miranda M.A.  Photophysical characterization and cytomic applications of cholylamidofluorescein, a fluorescent bile acid scaffold.  Anal Biochem (submitted). Manuscript.

 

Gómez-Lechón M.J., Donato M.T., Martínez-Romero A., Jiménez N., Castell J.V. and O´Connor J.E.  A human hepatocellular in vitro model to investigate steatosis.  Chemico-Biol Interact 165:106-116, 2007. 

Gómez-Lechón M.J., Castell J.V. and Donato M.T. Hepatocytes the choice to investigate drug metabolism and toxicity in man: In vitro variability as a reflection of in vivo.  Chemico-Biol Interact 168:30-50, 2007. 

 

 

Abstracts

Cvek B., Vrba J., Gómez-Lechón M.J. and Ulrichová J. In vitro models in the prediction of hepatoxicity in man. 46th ETCS International Meeting/3rd International Joint Meeting AICC-Celltox on "In Vitro Cytotoxicity Mechanisms" Verona, March 2006. Poster. Poster pdf 128 kB

Cvek B, Zdarilová A, Vrba J, Gómez-Lechón M.J. and Ulrichová J. CYTOXICITY OF MODEL COMPOUNDS ON  CELL LINES (3T3, HepG2) AND RAT HEPATOCYTES. 25th SSCT Workshop on in vitro toxicology, 19-22 September Salzau, Germany 2007.   Abstract pdf 64 kB

Pinto S., Diaz L., Herrera G., Gomez-Lechón M.J., Donato T., Castell J.V., Callaghan R.C.and O’Connor J.E. Application of high-content analysis to explore functional endpoints of cytotoxicity in primary cultures of hepatocytes.   Workshop "High Content Analysis",Madrid, March 2007. 

Ulrichová J., Cvek B., Zdarilová A., Vrba J. and Gómez-Lechón M.J. In vitro models in the prediction of metabolism and target organ specifity. III Meeting of the A-Cute-Tox Consortium, Ostende, October 2006. Poster.

Zdarilová A., Cvek B., Gómez-Lechón M.J. and Ulrichová J. Cytotoxicity of SAnguinarine and chelerythrine on different cell models. 24th SSCT Workshop on in vitro toxicology, September 7-9th, Grinda, Stockholm 2006.  Poster.