WP 7.3: Role target organ toxicity (liver)

 

Articles

Gómez-Lechón M.J., Donato M.T., Martínez-Romero A., Jiménez N., Castell J.V. and O´Connor J.E.  A human hepatocellular in vitro model to investigate steatosis.  Chemico-Biol Interact 165:106-116, 2007. 

Gómez-Lechón M.J., Castell J.V. and Donato M.T. Hepatocytes the choice to investigate drug metabolism and toxicity in man: In vitro variability as a reflection of in vivo.  Chemico-Biol Interact 168:30-50, 2007. 

 

Gui C., Miao Y., Thompson L., Wahlgren B., Mock M., Stieger B. and Hagenbuch B. Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. European Journal of Pharmacology 584,  57–65, 2008.


Rohacova J., Marin M.L., O’Connor J.E., Gómez-Lechón M.J., Donato M.T., Castell J.V and Miranda M.A.  Photophysical characterization and cytomic applications of cholylamidofluorescein, a fluorescent bile acid scaffold.  Anal Biochem (submitted). Manuscript.

Zdarilová A., Cvek B.,  Vrba J., Gómez-Lechón M.J. and Ulrichová J. Cytotoxicity of  model compounds on cell lines (3T3, HepG2) and rat hepatocytes.  Biomedical Papers, Vol. 1, 2008. 

 

 

Abstracts

Cvek B., Vrba J., Gómez-Lechón M.J. and Ulrichová J. In vitro models in the prediction of hepatoxicity in man. 46th ETCS International Meeting/3rd International Joint Meeting AICC-Celltox on "In Vitro Cytotoxicity Mechanisms" Verona, March 2006. Poster. Poster pdf 128 kB

Cvek B, Zdarilová A, Vrba J, Gómez-Lechón M.J. and Ulrichová J. CYTOXICITY OF MODEL COMPOUNDS ON  CELL LINES (3T3, HepG2) AND RAT HEPATOCYTES. 25th SSCT Workshop on in vitro toxicology, 19-22 September Salzau, Germany 2007.   Abstract pdf 64 kB

Pinto S., Diaz L., Herrera G., Gomez-Lechón M.J., Donato T., Castell J.V., Callaghan R.C.and O’Connor J.E. Application of high-content analysis to explore functional endpoints of cytotoxicity in primary cultures of hepatocytes.   Workshop "High Content Analysis",Madrid, March 2007. 

Ulrichová J., Cvek B., Zdarilová A., Vrba J. and Gómez-Lechón M.J. In vitro models in the prediction of metabolism and target organ specifity. III Meeting of the A-Cute-Tox Consortium, Ostende, October 2006. Poster.

Zdarilová A., Cvek B., Gómez-Lechón M.J. and Ulrichová J. Cytotoxicity of SAnguinarine and chelerythrine on different cell models. 24th SSCT Workshop on in vitro toxicology, September 7-9th, Grinda, Stockholm 2006.  Poster.