WP1: Generation of a database with toxicity data from animal tests and human accidents (in vivo data)

 

  WP1 Results pdf 98 kB , download the entire summary.

 

WP1 has been responsible for generation of an in vivo acute toxicity database for the 97 selected ACuteTox reference chemicals. The main purpose of this database is to enable evaluation and calibration of the data generated by in vitro toxicity testing in other WPs and in particular to allow validation of the ensuing in vitro test strategy.

 

Mammalian acute toxicity studies:

LD50 experiments derived from published literature. Over 2200 LD50 values have been compiled from rodent (rat, mouse) and other studies, including various administration routes (oral, intravenous, etc.).

 

Human acute poisoning cases:

Nearly 2800 human cases have been compiled, comprising three categories of single dose (exposure) acute poisoning, each with/without time information, viz: sub-lethal, lethal, and post-mortem.

 

Physicochemical properties:

WP1 has also contributed to compilation of physicochemical properties for the reference chemicals and summary descriptions, including toxicokinetic and pharmacokinetic data. All information about the chemicals has been entered into AcuBase.