WP8: Development of the testing strategy

 

 

 

Several meeting have been held in the consortium to discuss the composition of the testing strategy. It has been agreed that the following building blocks should be consider when the testing strategy and prediction model is created:

 

Box 1: Pre-existing information

Biological data, existing toxicity data such as LD50, info on relevant chemicals (read across), (Q)SAR, similarity searching corrosivity, inhalation/dermal data.

 

Box 2: Physico-chemical properties

A. Physico-chemical properties; Molecular weight etc., High insoluability
B. Deviation in in vitro biokinetics; High volatility, Binding to plastics, Protein binding,
C. Deviations in in vivo kinetics; Oral bioavailability, Biotransformation, Distribution.

 

Box 3: Simple test batteries using cell lines

Basal cytotoxicity

 

Box 4: Biokinetic modeling

A. Absorption
B. Biotransformation
C. Distribution

 

Box 5: Target organ toxicity

A. Haemapoetic toxicity
B. Immunotoxicity
C. Neurotoxicity
D. Nephrotoxicity
E. Livertoxicity

 

The work of WP8 has been moved to WP9 and will be a part of the pre-validation exercise. The final testing strategy and prediction model will be presented in the end of the project.