Development of in-vitro test strategy

 

The ultimate challenge of the ACuteTox project is to integrate the knowledge amassed into an expert system capable of providing a reliable value for a chemical’s acute in-vivo toxicity.

 

The integrated ACuteTox system developed will be capable of:

• predicting the in-vivo toxic dose of a chemical (based on the chemical’s physico-chemical, cytotoxicity and kinetic data in the databases),
• proposing which in-vitro tests to employ to experimentally quantify its acute toxicity and
• interpreting the results of the tests

to provide an authoritative value for a chemical’s acute in-vivo toxicity. The extensive work required to achieve this ambitious goal represents the core of the ACuteTox project.